Research

The Power of Innovation

At 3D VSP, we believe in the power of innovation. We collaborate closely with surgeons, hospitals, and research institutions to advance the medical field through cutting-edge 3D technologies. Our team develops and refines patient-specific 3D models that support scientific research, enhance surgical precision, and contribute to better patient outcomes.
The carousel below highlights some of our latest research efforts and partnerships.

Our latest publication on patient specific osteosynthesis for orthognatic surgery

Together with the Martini Hospital Groningen, we are studying the clinical accuracy of our patient specific osteosynthesis. The first results of our two-plate technique have been published. Follow-up results expected soon.

Indexed in: PubMed

Citescore: 4.1

Hylke van der Wel, Haye Glas, Johan Jansma and Rutger Schepers

“3D VSP Automatisering” receives EU funding

3D VSP was granted EU funding to work on replacing the manual, expert-driven workflows with digital, (semi-)automated pipeline. Parts of the project are automated segmentation, planning, fabrication and quality control. Using this project, we aim to boost capacity, cut errors and speed up the delivery of our patient specific instrumentation.

EU Funding: €26.500

Newly published PHD dissertation

With 3D VSP’s support, the dissertation ´Virtual Surgical Planning in patient-specific osteosynthesis’ has been published. This research explores advanced workflows and technologies such as AI-driven segmentation and customized implant design. Read the full thesis to learn about the methodology, key results, and potential clinical impact. We look forward to integrating these insights into our services and collaborating with partners to translate this cutting-edge research into improved patient outcomes.

Hylke van der Wel

Related Research

Accuracy of Patient-Specific Osteosynthesis in Bimaxillary Surgery: Comparative feasibility Analysis of Four- and Two-Miniplate fixation.
Authors: Van Der Wel, H., Glas, H., Jansma, J., & Schepers, R., Journal of Personalized Medicine, 15(5), 186.
Maxilla-first patient-specific osteosynthesis vs mandible-first bimaxillary orthognathic surgery using splints: a randomized controlled trial.
Authors: Van Der Wel, H., Schepers, R. H., Baan, F., Spijkervet, F. K. L., Jansma, J., & Kraeima, J. (2025), International Journal of Oral and Maxillofacial Surgery.
Accuracy of augmented reality navigated surgery for placement of zygomatic implants: a human cadaver study.
Authors: Heijtmeijer, S. T., Glas, H., Janssen, N., Vosselman, N., De Visscher, S., Spijkervet, F., Raghoebar, G., De Bree, R., Rosenberg, A., Witjes, M., & Kraeima, J. (2024), PeerJ
Mechanical ankle joint axis point on a Hip-to-Calcaneus long leg view correlates significantly with SPECT/CT activation in symptomatic asymmetric ankle osteoarthritis.
Authors: Spierenburg, W., De Vries, A., Van Der Wel, H., Kraeima, J., Dal, M., & Van Raaij, T. (2024)
Foot & Ankle International, 45(10), 1131–1138.
Facial masculinization surgery using Polyetheretherketone alloplasty: statistical shape modelling–based implant designs.
Authors: Van Der Wel, H., Merema, B. J., Kraeima, J., Schepers, R. H., & Jansma, J. (2024)
Plastic & Reconstructive Surgery Global Open, 12(7), e6012.
Calculating tumor Volume using Three-Dimensional Models in preoperative Soft-Tissue Sarcoma Surgical Planning: Does size matter?
Authors: Generaal, J. D., Glas, H. H., Ubbels, J. F., Stevenson, M. G., Huijing, M. A., Van Leeuwen, B. L., & Been, L. B. (2023)
Journal of Clinical Medicine, 12(23), 7242.
Development of a statistical shape model and assessment of anatomical shape variations in the hemipelvis.
Authors: Van Veldhuizen, W. A., Van Der Wel, H., Kuipers, H. Y., Kraeima, J., Duis, K. T., Wolterink, J. M., De Vries, J. P. M., Schuurmann, R. C. L., & IJpma, F. F. A. (2023)
Journal of Clinical Medicine, 12(11), 3767.
Morphological Variation of the Mandible in the Orthognathic Population—A morphological Study using Statistical shape Modelling.
Authors: Van Der Wel, H., Qiu, B., Spijkervet, F. K. L., Jansma, J., Schepers, R. H., & Kraeima, J. (2023)
Journal of Personalized Medicine, 13(5), 854.
Postoperative skeletal stability at the one-year follow-up after splintless Le Fort I osteotomy using patient-specific osteosynthesis versus conventional osteosynthesis: a randomized controlled trial.
Authors: Van Der Wel, H., Kraeima, J., Spijkervet, F., Schepers, R., & Jansma, J. (2022)
International Journal of Oral and Maxillofacial Surgery, 52(6), 679–685.
Three-Dimensional Evaluation of Isodose Radiation Volumes in Cases of Severe Mandibular Osteoradionecrosis for the Prediction of Recurrence after Segmental Resection.
Authors: Glas, H. H., Kraeima, J., Tribius, S., Leusink, F. K. J., Rendenbach, C., Heiland, M., Stromberger, C., Rashad, A., Fuller, C. D., Mohamed, A. S. R., Lai, S. Y., & Witjes, M. J. H. (2022)
Journal of Personalized Medicine, 12(5), 834.
Three-Dimensional Guided Zygomatic Implant Placement after Maxillectomy.
Authors: Vosselman, N., Glas, H. H., Merema, B. J., Kraeima, J., Reintsema, H., Raghoebar, G. M., Witjes, M. J. H., & De Visscher, S. A. H. J. (2022)
Journal of Personalized Medicine, 12(4), 588.
Two-Step 3D-Guided Supramalleolar Osteotomy to Treat Varus Ankle osteoarthritis.
Authors: Van Raaij, T., Van Der Wel, H., Beldman, M., De Vries, A., & Kraeima, J. (2022)
Foot & Ankle International, 43(7), 937–941.
Automatic Segmentation of Mandible from Conventional Methods to Deep Learning—A Review.
Authors: Qiu, B., Van Der Wel, H., Kraeima, J., Glas, H. H., Guo, J., Borra, R. J. H., Witjes, M. J. H., & Van Ooijen, P. M. A. (2021)
Journal of Personalized Medicine, 11(7), 629.
Mandible segmentation of dental CBCT scans affected by metal artifacts using Coarse-to-Fine learning model.
Authors: Qiu, B., Van Der Wel, H., Kraeima, J., Glas, H. H., Guo, J., Borra, R. J. H., Witjes, M. J. H., & Van Ooijen, P. M. A. (2021a)
Journal of Personalized Medicine, 11(6), 560.
Immediate implant-retained prosthetic obturation after maxillectomy based on zygomatic implant placement by 3D-guided surgery: a cadaver study.
Authors: Vosselman, N., Glas, H. H., De Visscher, S. A. H. J., Kraeima, J., Merema, B. J., Reintsema, H., Raghoebar, G. M., & Witjes, M. J. H. (2021)
International Journal of Implant Dentistry, 7(1).
Recurrent convolutional neural networks for 3D mandible segmentation in computed tomography.
Authors: Qiu, B., Guo, J., Kraeima, J., Glas, H. H., Zhang, W., Borra, R. J. H., Witjes, M. J. H., & Van Ooijen, P. M. A. (2021)
Journal of Personalized Medicine, 11(6), 492. h
Robust and accurate mandible segmentation on dental CBCT scans affected by metal artifacts using a prior shape model.
Authors: Qiu, B., Van Der Wel, H., Kraeima, J., Glas, H. H., Guo, J., Borra, R. J. H., Witjes, M. J. H., & Van Ooijen, P. M. A. (2021a)
Journal of Personalized Medicine, 11(5), 364.
Augmented Reality Visualization for Image-Guided Surgery: A Validation Study using a Three-Dimensional Printed Phantom.
Authors: Glas, H., Kraeima, J., Van Ooijen, P., Spijkervet, F., Yu, L., & Witjes, M. (2021)
Journal of Oral and Maxillofacial Surgery, 79(9), 1943.e1–1943.e10.
Three‐dimensional virtual surgical planning in the oncologic treatment of the mandible.
Authors: Kraeima, J., Glas, H. H., Merema, B. B. J., Vissink, A., Spijkervet, F. K. L., & Witjes, M. J. H. (2020)
Oral Diseases, 27(1), 14–20.
Patient‐specific finite element models of the human mandible: Lack of consensus on current set‐ups.
Authors: Merema, B. B. J., Kraeima, J., Glas, H. H., Spijkervet, F. K. L., & Witjes, M. J. H. (2020)
Oral Diseases, 27(1), 42–51.
The use of 3D virtual surgical planning and computer aided design in reconstruction of maxillary surgical defects.
Authors: Glas, H. H., Vosselman, N., & De Visscher, S. A. (2020)
Current Opinion in Otolaryngology & Head & Neck Surgery, 28(2), 122–128.
Automatic segmentation of the mandible from computed tomography scans for 3D virtual surgical planning using the convolutional neural network.
Authors: Qiu, B., Guo, J., Kraeima, J., Glas, H. H., Borra, R. J. H., Witjes, M. J. H., & Van Ooijen, P. M. A. (2019)
Physics in Medicine and Biology, 64(17), 175020.
Patient-specific pre-contouring of osteosynthesis plates for mandibular reconstruction: Using a three-dimensional key printed solution.
Authors: Kraeima, J., Glas, H., Witjes, M., & Schepman, K. (2018)
Journal of Cranio-Maxillofacial Surgery, 46(6), 1037–1040.
Accuracy and reproducibility of a newly developed tool for volume measurements of the arm using 3D stereophotogrammetry.
Authors: Verhulst, A., Wesselius, T., Glas, H., Vreeken, R., Ulrich, D., & Maal, T. (2017)
Journal of Plastic Reconstructive & Aesthetic Surgery, 70(12), 1753–1759.

The Power of Innovation

Our latest publication on patient specific osteosynthesis for orthognatic surgery

“3D VSP Automatisering” receives EU funding

Newly published PHD dissertation

Related Research

Connecting expertise for more sustainable care